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. 2020 Dec 17;11:593295. doi: 10.3389/fmicb.2020.593295

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Copyright © 2020 Wen, Chen, Luo, Zhao, Shu, Su, Zhao, Huang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MAPK/p38 pathway is involved in anti-apoptotic effect of up-regulated ZFAS1. (A–C) The detection of ERK (A), JNK (B), and p38 (C) activation after the usages of TNF-α and corresponding inhibitors by western blot. Second panel is the gray scale of left molecules band (ERK, JNK, or p38). Third panel is the relative levels of Bcl2/Bax. Right panel is the ratio of cleaved caspase 3/caspase 3. (D,E) The detection of ERK (D) and p38 (E) activation after the inhibition of ZFAS1 by western blot. Right panel is the gray scale of left molecules band (ERK or p38). ^*,#,&P < 0.05; ^∗∗∗P < 0.001; NS, no significance.