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. 2020 Oct 27;34(11):1191–1200. doi: 10.1007/s40263-020-00771-z
Next-generation, highly-selective S1PR modulator; exhibits highly affinity binding at S1PR1 and S1PR5
Reduces the risk of disability progression on EDSS; improves other clinical and MRI-defined outcomes of disability progression and disease activity (vs placebo)
Beneficial effects of treatment sustained
Generally well tolerated, with a safety profile similar to that of other S1PR modulators