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. 2020 Dec 17;8:604946. doi: 10.3389/fcell.2020.604946

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Copyright © 2020 Lin, Lee, Chang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The cbMSC-derived SCLCs promote neurite process sprouting. (A) Coculture of SCLCs with SH-SY5Y neuronal-like cells significantly promoted neurite formation, as indicated by the fluorescence images of neurite-specific protein βIII tubulin. (B) The number of neurites per neuron (n = 30 cells pooled from 2 independent experiments) and (C) the length of the longest neurite of each cell (n = 20 cells pooled from 2 independent experiments) were estimated (mean ± s.d.). Scale bars: 100 μm. **P < 0.01; ***P < 0.005; ****P < 0.001; ns, not significant.