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. 2020 Dec 17;8:604946. doi: 10.3389/fcell.2020.604946

Figure 4.

Figure 4

3D SCLC spheroids were transplanted into crush-injured rat sciatic nerves to promote regeneration. (A) Representative fluorescent images showing the retention of transplanted cells labeled with red fluorescence protein (RFP) in sciatic nerve tissues at 1 h postoperation. Orange box is enlarged in right panel. Scale bars: 200 μm. (B) Representative hind feet tracks of mice recorded 4 weeks after cell transplantation and (C) the corresponding sciatic function index (SFI). The dashed boxes highlight the prints of the experimental feet (n = 3, mean ± s.d.). *P < 0.05 vs. saline group; **P < 0.01 vs. saline group; ***P < 0.005 vs. saline group; P < 0.05 vs. cbMSC-suspension group; #P < 0.05 vs. SCLC-suspension group; ##P < 0.01 vs. SCLC-suspension group. (D) Expression of βIII tubulin and myelin basic protein (MBP) determined by immunofluorescence staining. The dotted lines indicate the borders of injury sites. Scale bars: 500 μm.