FIGURE 4.

Potency of lead compounds combined with DEX in inhibiting CXCL8 production. Compounds 1–1; (A), 1–2; (B) and 3–1; (C) were added at the indicated concentrations and DEX was added at 100 nM with 0.04% final concentration of DMSO as vehicle to TNF 2 ng/ml stimulated THP-1 cells overnight. CXCL8 was measured in the supernatant. Data are represented as mean ± SEM and indicates p < 0.05, **p < 0.01, ***p < 0.001, & p < 0.0001 by two way ANOVA with Bonferroni post hoc test comparing compound vs. compound + DEX. Data are representative of two independent experiments showing similar results.