FIGURE 5.

Synergistic effects of lead compounds with DEX in suppressing TNF stimulated CXCL8 production. Compounds 1–1; (A), 1–2; (B) and 3–1; (C) and DEX were titrated to the indicated concentrations and added to TNF 2 ng/ml stimulated THP-1 cells overnight and CXCL8 measured in the supernatant. Vehicle was 0.04% DMSO. Data are represented as mean ± SEM. (D) Potency ratios were calculated and presented as isobolograms. The dotted line represents additivity between DEX and the compounds. Data are representative of two independent experiments showing similar results.