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. 2020 Dec 17;11:607713. doi: 10.3389/fphar.2020.607713

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Copyright © 2020 Hosoya, Shukla, Fujita, Yao, Lao, Baba, Yasuda, Cottam, Carson, Hayashi and Corr

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synergistic suppression of CXCL8 and IL-6 production by compound 1–1 and DEX. Levels of CXCL8; (A) and IL-6; (B) secreted into the supernatant by RA FLS stimulated overnight with 1 ng/ml of TNF and treated with the indicated concentrations of 1–1 and DEX were measured by ELISA. Data are represented as mean ± SEM. Potency ratios were calculated and presented as isobolograms for CXCL8; (C) and IL-6; (D). The dotted line represents additivity between DEX and the compounds. Data are representative of two independent experiments showing similar results.