TABLE 1.

Number of compounds in lead chemotype clusters by screening stage.

Chemotype cluster number	Chemotype	Number in 1824 starting compounds	Number passed all selection criteria	Selection or exclusion criteria
1	1H-pyrazolo [3,4 d] pyrimidin-4-amine	22	11	Selected
2	(E)-5-benzylidene imidazolidine-2,4-dione	17	4	Excluded as a michael acceptors
3	Bis-aryl urea	12	1	Selected
5	2-Nitro furan arylamide	9	5	Selected
6	Piperidine derivatives	9	2	Weak inhibition
8	(E)-3-phenyl-1-(quinolin-3-yl)prop-2-en-1-one	8	3	Excluded as a michael acceptor
10	1H-pyrazolo [3,4-b] quinolin-3-amine	6	2	None commercially available
13	2-Imino-1,2-dihydro-5H-dipyrido [1,2-a:2′,3′-d]pyrimidin-5-one	5	3	Selected
15	Piperazine derivatives	5	1	None commercially available
16	(E)-3-phenyl-1-(pyridin-3-yl)prop-2-en-1-one	3	1	Excluded as a michael acceptors
17	Thiophene pyrazine piperidine analogs	3	2	Selected
18	Pyrazole derivatives	22	2	None commercially available
n/a	Singleton compounds	n/a	14	Excluded