Table 4.
Dosimetric parameters for PTV and main OARs in FF-IMRT, VMAT, and TOMO plans.
| Parameters | FF-IMRT | VMAT | TOMO | P* | ||
|---|---|---|---|---|---|---|
| VMAT Vs. FF-IMRT | TOMO Vs. FF-IMRT | TOMO Vs. VMAT | ||||
| PTV | ||||||
| Dmean (Gy) | 46.04 ± 0.14 | 46.05 ± 0.09 | 46.17 ± 0.20 | 0.945 | 0.076 | 0.035 |
| HI | 0.053 ± 0.005 | 0.053 ± 0.005 | 0.046 ± 0.005 | 1.000 | <0.001 | <0.001 |
| CI | 0.883 ± 0.023 | 0.889 ± 0.017 | 0.901 ± 0.016 | 0.014 | <0.001 | <0.001 |
| Bone marrow | ||||||
| V10 (%) | 80.99 ± 2.10 | 82.30 ± 2.67 | 85.73 ± 0.54 | 0.013 | <0.001 | <0.001 |
| V20 (%) | 58.26 ± 1.10 | 57.60 ± 1.00 | 62.69 ± 1.00 | 0.061 | <0.001 | <0.001 |
| V30 (%) | 35.97 ± 1.32 | 35.27 ± 1.73 | 40.67 ± 1.12 | 0.062 | <0.001 | <0.001 |
| V40 (%) | 14.71 ± 1.47 | 14.91 ± 1.63 | 14.70 ± 1.63 | 0.450 | 0.956 | 0.334 |
| Dmean (Gy) | 24.49 ± 2.55 | 23.86 ± 0.27 | 25.56 ± 0.68 | 0.350 | 0.139 | <0.001 |
| Small intestine | ||||||
| V10 (%) | 82.12 ± 4.25 | 83.74 ± 4.77 | 91.45 ± 4.32 | <0.001 | <0.001 | <0.001 |
| V20 (%) | 65.05 ± 5.62 | 61.82 ± 6.22 | 61.59 ± 6.73 | <0.001 | <0.001 | 0.758 |
| V30 (%) | 37.58 ± 7.37 | 37.63 ± 6.41 | 36.82 ± 7.74 | 0.894 | 0.137 | 0.118 |
| V40 (%) | 18.29 ± 5.44 | 18.16 ± 5.58 | 16.53 ± 5.39 | 0.460 | <0.001 | 0.002 |
| Dmax (Gy) | 47.16 ± 0.31 | 47.21 ± 0.29 | 46.98 ± 0.32 | 0.541 | 0.06 | 0.005 |
| Rectum | ||||||
| V10 (%) | 97.66 ± 2.88 | 98.28 ± 2.43 | 99.03 ± 1.74 | 0.001 | 0.010 | 0.071 |
| V20 (%) | 93.52 ± 3.30 | 95.30 ± 3.53 | 83.12 ± 7.90 | <0.001 | <0.001 | <0.001 |
| V30 (%) | 74.85 ± 3.91 | 75.95 ± 3.75 | 54.06 ± 7.59 | 0.378 | <0.001 | <0.001 |
| V40 (%) | 35.96 ± 6.85 | 38.20 ± 4.57 | 27.26 ± 5.40 | 0.208 | <0.001 | <0.001 |
| Dmax (Gy) | 45.70 ± 0.52 | 43.90 ± 7.57 | 46.45 ± 0.53 | 0.360 | <0.001 | 0.202 |
| Bladder | ||||||
| V10 (%) | 98.19 ± 1.98 | 99.29 ± 1.25 | 100 ± 0.00 | 0.014 | 0.003 | 0.045 |
| V20 (%) | 82.41 ± 3.69 | 85.28 ± 5.94 | 92.55 ± 10.54 | 0.025 | <0.001 | 0.008 |
| V30 (%) | 64.57 ± 2.01 | 63.39 ± 2.62 | 61.45 ± 5.20 | 0.108 | 0.023 | 0.201 |
| V40 (%) | 43.51 ± 5.21 | 42.38 ± 5.45 | 35.89 ± 4.50 | 0.039 | <0.001 | <0.001 |
| Spinal Cord | ||||||
| Dmax (Gy) | 17.70 ± 3.74 | 13.98 ± 2.32 | 22.42 ± 3.75 | <0.001 | 0.006 | <0.001 |
| Femoral head-L | ||||||
| V10 (%) | 78.96 ± 9.71 | 86.80 ± 10.09 | 98.67 ± 2.00 | 0.005 | <0.001 | 0.001 |
| V20 (%) | 37.61 ± 5.73 | 29.48 ± 8.31 | 66.52 ± 9.96 | 0.002 | <0.001 | <0.001 |
| V30 (%) | 11.74 ± 4.95 | 4.98 ± 3.30 | 29.41 ± 11.35 | <0.001 | <0.001 | <0.001 |
| V40 (%) | 0.687 ± 1.308 | 0.089 ± 0.204 | 0.235 ± 0.593 | 0.078 | 0.221 | 0.349 |
| Femoral head-R | ||||||
| V10 (%) | 77.25 ± 8.59 | 82.96 ± 7.79 | 98.92 ± 1.99 | 0.043 | <0.001 | <0.001 |
| V20 (%) | 34.06 ± 6.52 | 26.89 ± 12.49 | 66.22 ± 9.23 | 0.064 | <0.001 | <0.001 |
| V30 (%) | 10.44 ± 5.59 | 4.29 ± 5.32 | 25.72 ± 10.61 | <0.001 | <0.001 | <0.001 |
| V40 (%) | 0.564 ± 1.416 | 0.066 ± 0.144 | 0.058 ± 0.201 | 0.161 | 0.190 | 0.888 |
| Treatment time (s) | 583.53 ± 22.88 | 294.13 ± 12.55 | 760.33 ± 53.48 | <0.001 | <0.001 | <0.001 |
*P value was computed by paired t test.