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Recruitment of neocortical disinhibitory microcircuits in fear-related behaviors. Disinhibitory connectivity in the medial prefrontal cortex (mPFC) during social fear expression. Left: the behavioral paradigm of the social fear expression. Right: social stimuli recruit SST+ inhibitory interneurons (INs) which strongly inhibit PV+ INs and trigger disinhibition of the projecting principal neurons (PNs) in the mPFC.
