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. 2020 Dec 17;11:587176. doi: 10.3389/fphar.2020.587176

FIGURE 2.

FIGURE 2

Effects of Bufei Jianpi formula (BJF) on COPD rats. (A) Body weight and pulmonary function [data are presented as mean ± SD (n = 6 per group)], (B) lung histomorphology, with red arrow indicating airway wall thickening, yellow arrow indicating pulmonary alveoli wall rupture, and blue arrow indicating inflammatory cell infiltration [hematoxylin and eosin (HE) staining, magnification ×100, scale bar = 100 μm], (C) skeletal muscle histomorphology, with red arrow indicating the increased intervals between muscle fibers, yellow arrow indicating muscle fiber atrophy and blue arrow indicating muscle fibers disarrangement (HE staining, magnification ×200, scale bar = 200 μm), and (D) skeletal muscle ultrastructure, with red arrow indicating mitochondrial autophagosomes fusing with lysosomes and yellow arrow indicating mitochondria complicated with vacuoles (magnification ×50,000). AICAR, 5-aminoimidazole-4-carboxamide ribonucleotide; APL, aminophylline.