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. 2020 Dec 17;8:547653. doi: 10.3389/fcell.2020.547653

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Copyright © 2020 Ramezankhani, Torabi, Minaei, Madani, Rezaeiani, Hassani, Gee, Dominici, Silva, Baharvand and Hajizadeh-Saffar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The percent of approved cell, gene, and tissue engineering products, along with their related indications and product type (autologous or allogeneic). (A) The CTMPs with 34 members constitute the largest class of ATMPs. Most of these products have an autologous source. Hematologic disorders, along with skin and soft tissue related disorders and orthopedic disorders constitute the main fields. (B) The TEPs, with 20 products, represent the next largest class of ATMPs. The most emphasized indications in this class are skin and soft tissue related disorders, orthopedic disorders, and cardiovascular diseases, respectively, and the percentage of allogeneic products are more than autologous products. (C) GTMPs with 10 products comprise the last class. The first common indications are oncology, hematologic disorders, and cardiovascular diseases, respectively. Similar to CTMPs, GTMP members mostly have autologous sources.