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. 2020 Dec 17;14:610898. doi: 10.3389/fnins.2020.610898

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Copyright © 2020 Ho, Chen, Chang, Lin, Tsai, Lin and Liou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of JMF1907 and J4 on sEPSCs recorded from hippocampal granule cells. (A,B) Sample traces of sEPSCs from wild-type mice before and after 1 μg L^{– 1} JMF1907 and J4 perfusion. The cumulative histograms were obtained from the same neurons illustrated in panel (A,B) before and after drugs treatment. The result showed a decrease in sEPSCs frequency (C,D, as measured by the inter-event intervals, p < 0.0001) but not amplitude (G, p = 0.54; H, p = 0.66, Kolmogorov–Smirnov test) after JMF1907 and J4 treatment. (E,F,I,J) Changes in the average frequency and amplitude of sEPSCs after 0.05-, 1-, and 10 μg L^{– 1} JMF1907 and J4 application. These results indicate that both JMF1907 and J4 can reduce the sEPSCs frequency in a dose-dependent manner. Data are given as mean ± SEM (n = 3–5 neurons per group obtained from 2 to 3 animals). Statistical significance (*p < 0.05) was evaluated with Student’s t–test.