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. 2020 Dec 17;8:584800. doi: 10.3389/fcell.2020.584800

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Copyright © 2020 Li, Gao, Jiang, Qin and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagrams of mitochondrial dynamism proteins. (A) The dynamin-related protein 1 (Drp1) is the major mitochondrial fission protein, with GTPase activity. The anchored adapter proteins, fission protein 1 (Fis1), mitochondrial fission factor (MFF), and mitochondrial dynamics proteins of 49 kDa and 51 kDa (MID49/51) also participate in the fission process. (B) Mitofusin 1/2 (Mfn1/2) and optic atrophy 1 (OPA1) mediate the mitochondrial fusion process. Their normal functions rely on the activity of GTPases. The structures of Mfn1 and Mfn2 are similar. They have about 80% sequence similarity.