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Fused and fragmented mitochondria in adult cardiomyocytes. (A) Normal mitochondria in the adult cardiac. (B) Fused mitochondria in adult cardiomyocytes with dynamin-related protein 1 (Drp1) inhibition; the white arrows indicate that the mitochondria were fused from 2–3 normal-sized mitochondria. (C) Fragmented mitochondria in the Mfn1/2 knockout adult cardiomyocytes: mitochondrial size is decreased, and mitochondria have become round.
