Table 1.
Multivariate GLM of the headache intensity in patients hospitalized because of COVID-19.
| Coefficient and 95% CI | Unadjusted p-value | Adjusted p-value (FDR) | |
|---|---|---|---|
| Intensity model | |||
| Independent term | 3.70 (1.84, 5.55) | <0.001 | 0.001 |
| Treatment resistant | −0.74 (−1.29, −0.19) | 0.010 | 0.032 |
| Sex (Female vs. Male) | 1.18 (0.65, 1.72) | <0.001 | <0.001 |
| Aggravation by physical activity | 2.13 (0.47, 3.79) | 0.014 | 0.039 |
| Quality of headache | |||
| Pulsating vs. pressing | 2.06 (1.09, 3.03) | <0.001 | <0.001 |
| Stabbing vs. pressing | 1.60 (0.60, 2.59) | 0.002 | 0.010 |
| Aggravation by head movement | −1.37 (−2.96, 0.23) | 0.096 | 0.11 |
| Lightheadedness | −0.76 (−1.49, −0.03) | 0.044 | 0.076 |
| Abnormal platelets on admission | −0.71 (−1.44, 0.01) | 0.058 | 0.076 |
| High blood pressure comorbidity | −0.63 (−1.18, −0.08) | 0.029 | 0.069 |
| Progressive | 0.54 (−0.14, 1.22) | 0.12 | 0.13 |
| Headache as first COVID-19 symptom | 0.61 (−0.00, 1.22) | 0.054 | 0.076 |
| Phonophobia and photophobia | 0.62 (0.02, 1.23) | 0.047 | 0.076 |
| Expectoration | 0.82 (0.07, 1.56) | 0.034 | 0.073 |
| TTH—Criterion C | 0.87 (−0.11, 1.85) | 0.086 | 0.10 |
| Pathologic chest X-Ray | 1.37 (0.02, 2.73) | 0.050 | 0.076 |
| Disability model | |||
| Independent term | 12.36 (−9.53, 34.24) | 0.27 | 0.27 |
| Lightheadedness | −14.17 (−24.81, −3.53) | 0.011 | 0.030 |
| Abnormal platelet count on admission | −12.53 (−22.85, −0.20) | 0.020 | 0.042 |
| Treatment resistant | −9.99 (−17.84, −2.13) | 0.015 | 0.036 |
| Aggravation by physical activity | 12.16 (4.26, 20.06) | 0.003 | 0.029 |
| Phonophobia and photophobia | 12.78 (3.97, 21.60) | 0.006 | 0.030 |
| Sex (Female vs. Male) | 14.03 (5.36, 22.70) | 0.002 | 0.029 |
| Fever | 14.65 (2.10, 27.20) | 0.025 | 0.047 |
| Expectoration | 14.88 (3.98, 25.79) | 0.009 | 0.030 |
| Leukocyte count on admission | 0.0020 (0.0005, 0.0034) | 0.010 | 0.030 |
| Smoking (previous or current) | −10.59 (−23.49, 2.31) | 0.11 | 0.13 |
| Use of Angiotensin-converting-enzyme inhibitors and angiotensin II receptors | −7.66 (−16.29, 0.98) | 0.086 | 0.11 |
| Days from admission to worst lymphocyte count | −0.60 (−1.21, 0.01) | 0.056 | 0.080 |
| Neurological symptoms of headache | 8.51 (−2.00, 19.01) | 0.12 | 0.13 |
| Bilateral diffuse pain | 8.21 (0.54, 15.88) | 0.039 | 0.060 |
| Quality of headache | |||
| Pulsating vs. pressing | 12.93 (1.24, 24.62) | 0.033 | 0.056 |
| Stabbing vs. pressing | 10.53 (−2.82, 23.87) | 0.13 | 0.13 |
The bold terms show statiscally significant variables after the FDR correction (if a p-value is provided for the variable) or indicate a specific model.