FIGURE 3.

The SARS-CoV-2 replication-transcription complex. (A) Schematic representation of the non-structural proteins that were reported to intervene during the distinct steps of viral RNA replication. Endoplasmic reticulum rearrangements are performed by the Nsp3-5-6 subcomplex resulting in recruitment of the Nsp proteins, initiating RNA synthesis, proof-reading and capping. (B) Structural representation of the proteins involved in viral RNA replication, as shown in (A). Where protein structures have been determined, cartoon models of the molecular structures are represented, whilst proteins with no structural details are depicted as colored shapes, as in part A. Relative positions and molecular contacts between Nsp proteins represented are based on the experimental evidence reviewed in this manuscript, while putative localization have been provided for those protein whose interaction network is still not determined. PDB IDs for the structures depicted in these figures are reported in Table 1.