Table 3.
Perioperative parameters and pathological response regarding TTS after NACT in 426 patients.
| All patients | ≤ 21d (n = 49) | 21–28d (n = 93) | 28–35d (n = 108) | 35-42d (n = 84) | 42–84d (n = 92) | P | |
|---|---|---|---|---|---|---|---|
| Hospital stay (days)* | 10 (9,14) | 13 (10, 16) | 10 (9, 12) | 10 (9, 13) | 10.5 (9,14) | 11 (9,14) | <0.001 |
| Operative time (min)* | 203 (172, 239) | 205 (171, 240) | 215 (179, 248) | 198.5 (166, 227.5) | 207.5 (186.5, 252.5) | 201 (170, 229.5) | 0.146 |
| Blood loss (ml)* | 100 (100, 150) | 100 (100, 200) | 100 (99, 150) | 100 (75, 173.5) | 100 (100, 200) | 100 (100, 150) | 0.143 |
| The number of resected lymph nodes* | 30 (23, 39) | 31 (24, 36) | 30 (23, 40) | 30 (24.5, 39) | 29.5 (22, 38.5) | 30 (23, 39) | 0.978 |
| Clavien-Dindo | 0.369 | ||||||
| 0 | 297 (69.72) | 30 (61.22) | 70 (75.21) | 81 (75.00) | 56 (66.67) | 60 (65.22) | |
| I-II | 87 (21.22) | 9 (18.37) | 15 (16.13) | 11 (10.19) | 16 (19.05) | 17 (18.48) | |
| III-IV | 60 (14.63) | 10 (20.41) | 8 (8.60) | 16 (14.81) | 12 (14.29) | 15 (16.30) | |
| Fever for unknown origin | 57 (13.90) | 32 (12.26) | 25 (16.78) | 0.203 | |||
| Abdominal infection/abscess | 37 (8.69) | 6 (12.24) | 9 (9.68) | 7 (6.48) | 6 (7.14) | 9 (9.78) | 0.745 |
| Hemorrhage or transfusion | 21 (4.93) | 2 (4.08) | 2 (2.15) | 6 (5.56) | 6 (7.14) | 5 (5.43) | 0.622 |
| Moderate to massive ascites | 42 (9.86) | 6 (12.24) | 10 (10.75) | 10 (9.26) | 8 (9.52) | 8 (8.70) | 0.964 |
| Anastomotic leak | 26 (6.10) | 6 (8.16) | 6 (6.45) | 4 (3.70) | 5 (5.95) | 7 (7.61) | 0.766 |
| Ileus | 11 (2.58) | 0 (0.00) | 1 (1.08) | 3 (2.78) | 3 (3.75) | 4 (4.35) | 0.500 |
| Gastroparesis | 10 (2.35) | 2 (4.08) | 1 (1.08) | 3 (2.78) | 1 (1.19) | 3 (3.26) | 0.697 |
| Lymphatic leakage | 7 (1.64) | 4 (8.16) | 1 (1.08) | 1 (0.93) | 0 (0.0) | 1 (1.09) | 0.012 |
| Unexpected reoperation | 6 (1.41) | 2 (4.08) | 1 (1.08) | 2 (1.85) | 1 (1.19) | 0 (0.00) | 0.375 |
| Systemic complications | |||||||
| Pulmonary complicationsa | 52 (12.21) | 9 (18.37) | 6 (6.45) | 11 (10.19) | 13 (15.48) | 13 (14.13) | 0.183 |
| Cardiovascular complicationsb | 10 (2.35) | 1 (2.04) | 3 (3.23) | 0 (0.00) | 2 (2.38) | 4 (4.35) | 0.228 |
| Other vascular complicationsc | 4 (0.94) | 1 (0.00) | 1 (1.08) | 2 (1.85) | 1 (1.19) | 0 (0.00) | 0.873 |
| Delirium | 4 (0.94) | 0 (0.00) | 1 (1.08) | 0 (0.00) | 3 (3.57) | 0 (0.00) | 0.056 |
| ypT0 | 32 (7.51) | 3 (6.12) | 6 (6.45) | 7 (6.48) | 10 (11.90) | 6 (6.52) | 0.572 |
| ypN0 | 196 (46.01) | 23 (46.94) | 41 (44.09) | 52 (48.15) | 42 (50.00) | 38 (41.30) | 0.789 |
| pCR | 29 (6.81) | 3 (6.12) | 5 (5.38) | 5 (4.63) | 10 (11.90) | 6 (6.52) | 0.387 |
Values in parentheses are percentages unless indicated otherwise.
*Values are median (IQR).
TTS, time to surgery; pCR, pathological complete response.
aPulmonary complications include moderate to massive pleural effusion and pneumonia.
bCardiovascular complications include atrial fibrillation and acute myocardial infarction.
cOthers vascular complications include deep vein thrombosis and pulmonary embolism.