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. 2020 Dec 10;24(1):101919. doi: 10.1016/j.isci.2020.101919

Figure 4.

Figure 4

Structural equivalence of hydroxyl groups of glucose/sphingosine

(A–F) (A) Relevant section of Gal-8N complexed with the sulfatide-1 as 2Fo-Fc electron density map contoured at 1.0 σ (protein drawn in cartoon-style, sulfatide-1 and contact residues in ball-and-stick mode and water molecules red spheres) at two levels of magnification and (B) profile of interactions, highlighting sphingosine's OH group and the mobile acyl section of the amide. Comparative illustration of the relevant sections of Gal-8N-ligand complexes for suLac (PDB: 3AP6; C) and for sulfatide-1 (D) showing the structural equivalence of the hydroxyl groups of sugar (C) and sphingosine (D). This is also seen for Gal-4N-ligand complexes, i.e. Gal-4-N with suLac (PDB: 5DUW); (E) and the correspondingly modeled complex with sulfatide-1 (F).