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. 2020 Dec 17;8:610544. doi: 10.3389/fbioe.2020.610544

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Copyright © 2020 Silini, Di Pietro, Lang-Olip, Alviano, Banerjee, Basile, Borutinskaite, Eissner, Gellhaus, Giebel, Huang, Janev, Kreft, Kupper, Abadía-Molina, Olivares, Pandolfi, Papait, Pozzobon, Ruiz-Ruiz, Soritau, Susman, Szukiewicz, Weidinger, Wolbank, Huppertz and Parolini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure and cell populations from the umbilical cord. (A) Schematic structure of the human umbilical cord showing the presence on the surface of the amniotic membrane (hUC-AM) made of hUC-AEC and hUC-AMSC and the different regions of Wharton’s jelly (subamniotic, intermediate and perivascular). hUC-WJ-MSC, human umbilical cord Wharton’s jelly mesenchymal stromal cells; hUC-PVC, human umbilical cord perivascular cells; hUC-V, human umbilical cord vascular region; hUC-VSMC, human umbilical cord vascular smooth muscle cells. Histological images (Haematoxylin-eosin) of (B) hUC at low magnification (10x) showing the presence of two umbilical arteries (light blue arrows) surrounded by human umbilical cord Wharton’s jelly (hUC-WJ), (C) umbilical artery at higher magnification (20x) showing the presence of human umbilical cord perivascular cells (hUC-PV), (D) intermediate region of Wharton’s jelly showing at higher magnification (40x) the presence of numerous mesenchymal stromal cells (hUC-iWJ-MSC).