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. 2020 Dec 17;8:590898. doi: 10.3389/fcell.2020.590898

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Copyright © 2020 Dong, Song, Hu, Zheng, Zhang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TBX22 was downregulated in PTC cell lines and attenuated the capability of proliferation. (A) Relative TBX22 mRNA expression levels were significantly lower in thyroid cancer cell lines (BCPAP, TPC-1, and KTC-1) compared with the normal thyroid epithelial cell line HTori-3. (B) Transcriptional level of TBX22 in si-NC and si-TBX22 transfected PTC cells via qRT-PCR. (C) Transcriptional level of TBX22 in VECTOR and TBX22-OE group via qRT-PCR. (D,E) CCK-8 assays determined the cell viability of (D) loss-of-TBX22 and (E) gain-of-TBX22 PTC cells. (F) Colony formation assays were used to determine the cell colony formation ability of loss-of-TBX22 and gain-of-TBX22 PTC cells. Student’s t-test was used in comparison with the si-NC or VECTOR groups. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 in data analysis, and all assays were repeated at least three times.