Figure 7.

Macrovesicular steatosis in HLCs does not correlate with wide-scale changes in 5hmC enrichment

(A) Correlation heatmap of control versus LPO groups, following hmeDIP sequencing, clustered by Euclidean distance.

(B) Proportion of DHRs associated with different regions of the genome, showing the majority located in intragenic and intronic regions.

(C) Heatmap of DHRs, with an FDR of <0.05 and k-means clustering.

(D) Sliding window analysis of the transcriptional start site (TSS), gene body, and transcriptional end site (TES) shows minimal changes between control and LPO groups. For both control and LPO, n = 3 biological replicates/group.