Table 4.

Mean SOS (m/s) according to the severity of radiographic knee OA stratified by sex.

KL grades	0	1	2	3	4	P for trend‡
Male	(n=661)	(n=539)	(n=300)	(n=182)	(n=70)
Unadjusted	4034.42 ​± ​7.81	4046.90 ​± ​8.64	4060.44 ​± ​11.59	3977.30 ​± ​14.88†	3942.87 ​± ​23.99†	<0.001
Model 1	4028.30 ​± ​10.95	4047.76 ​± ​8.71	4063.83 ​± ​12.34	3985.33 ​± ​17.97†	3958.58 ​± ​31.05†	<0.001
Model 2	4029.09 ​± ​11.22	4047.76 ​± ​8.71	4063.33 ​± ​12.44	3984.14 ​± ​18.33†	3956.43 ​± ​31.75†	<0.001
Female	(n=696)	(n=567)	(n=311)	(n=515)	(n=332)
Unadjusted	4017.60 ​± ​7.18	4031.16 ​± ​7.96	4040.28 ​± ​10.74	3946.94 ​± ​8.35†	3916.04 ​± ​10.40†	<0.001
Model 1	4018.15-±11.75	4031.28 ​± ​8.20	4040.24 ​± ​10.76	3946.61 ​± ​10.02†	3915.22 ​± ​17.28†	<0.001
Model 2	4018.16 ​± ​12.03	4031.29 ​± ​8.28	4040.24 ​± ​10.76	3946.60 ​± ​10.25†	3915.21 ​± ​17.68†	<0.001

Values are the means ​± ​standard error (SE).

‡P for trend values by general linear models.

∗P ​< ​0.05, †P ​< ​0.01 by post hoc analyses, KL grade 2 subgroup as reference.

Model 1, adjusted for age.

Model 2, adjusted for age and BMI.

SOS, speed of sound; OA, osteoarthritis; KL, Kellgren-Lawrence; BMI, body mass index.