Anti-inflammatory LZ-SMS suppress pro-inflammatory cytokines in plasma and synovial fluid. The Bar charts are shown the levels of (A) plasma and (B) synovial fluid cytokines including IL-12p70, IL-17A, TNF-α, INF-γ, IL-6 and IL-10 from different treated groups. Differences among treatments are compared by one-way ANOVA (n = 5/group, #p < 0.05, ##p < 0.01, ACLT vs. other groups). Wilcoxon test is used to assess the differences between two different treatments (n = 5/group,∗p < 0.05, HA+LZ-SMS vs. other groups).