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. 2020 Oct 21;26:132–140. doi: 10.1016/j.jot.2020.07.008

Figure 4.

Figure 4

Micro-architecture of subchondral bone in the ACLT induced OA rats. (A) 3-view micro-CT images of the right hind knee joint of rats with different treatment. Blue arrow pointed blue rectangle is shown the region of interest (ROI) in Sham group. Blue arrow pointed bone erosion is shown in ACLT group. Red arrow pointed bone sclerosis at distal medial tibial SCB plate is shown in LZ-SMS and ACLT groups. Green arrow pointed SCB cysts are shown in ACLT and HA groups. (B) 3D micro-CT reconstruction images of the ROI under the loadbearing area of medial tibial SCB from rats with different treatment. (C) The Bar charts are shown with the mean values of detailed micro-architectural parameters of medial tibial SCB. Differences among each parameter are compared by one-way ANOVA (n ​= ​5/group, #p ​< ​0.05, ##p ​< ​0.01, ###p ​< ​0.0001, ACLT vs. other groups). Wilcoxon test is used to assess the differences between two different treatments (n ​= ​5/group, ∗p ​< ​0.05, ∗∗p ​< ​0.01; ∗∗∗p ​< ​0.0001, HA+LZ-SMS vs. other groups). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)