Supplementary Table 5.
OTUs With Significantly Different Relative Abundance in Fecal Samples of 18 TCD Children and Their Unaffected 19 Siblings
| Base Mean | Log2-fold Change | P | P (Adjusted) | Higher in | |
|---|---|---|---|---|---|
| OTU_38 [Eubacterium] coprostanoligenes group | 75.9 | 5.27 | 3.09E-12 | 1.88E-09 | Siblings |
| OTU_107 Prevotella 7 | 42.2 | 5.05 | 7.62E-10 | 2.32E-07 | Siblings |
| OTU_111 Blautia | 34.0 | 4.17 | 4.98E-09 | 1.01E-06 | Siblings |
| OTU_62 Ruminococcaceae UCG-014 | 19.1 | 4.01 | 3.05E-08 | 4.65E-06 | Siblings |
| OTU_114 Coprococcus 2 | 12.9 | 3.85 | 9.00E-08 | 1.10E-05 | Siblings |
| OTU_568 Bifidobacterium bifidum NCIMB 41171 | 232.0 | 4.26 | 2.10E-07 | 1.72E-05 | Siblings |
| OTU_135 Holdemanella | 10.6 | 3.39 | 2.26E-07 | 1.72E-05 | Siblings |
| OTU_143 Ruminococcus 1 | 9.9 | 3.51 | 2.18E-07 | 1.72E-05 | Siblings |
| OTU_295 Christensenellaceae R-7 group | 6.8 | 3.43 | 4.18E-07 | 2.83E-05 | Siblings |
| OTU_1059 [Eubacterium] coprostanoligenes group | 8.5 | 3.61 | 2.93E-06 | 1.79E-04 | Siblings |
| OTU_228 Faecalibacterium | 6.5 | 3.36 | 3.61E-06 | 2.00E-04 | Siblings |
| OTU_212 Ruminiclostridium 9 | 7.5 | 2.73 | 6.28E-06 | 3.06E-04 | Siblings |
| OTU_74 [Eubacterium] ruminantium group | 5.7 | 3.18 | 6.53E-06 | 3.06E-04 | Siblings |
| OTU_78 Ruminiclostridium 5 | 11.2 | –3.08 | 1.11E-05 | 4.60E-04 | TCD |
| OTU_140 Collinsella | 6.9 | 3.13 | 1.13E-05 | 4.60E-04 | Siblings |
| OTU_230 Bacteroides | 6.8 | –2.84 | 1.21E-05 | 4.62E-04 | TCD |
| OTU_299 [Ruminococcus] gauvreauii group | 9.2 | –2.72 | 1.71E-05 | 6.07E-04 | TCD |
| OTU_324 Peptococcaceae | 4.7 | 2.60 | 1.79E-05 | 6.07E-04 | Siblings |
| OTU_88 Bacteroides | 954.3 | –2.89 | 1.95E-05 | 6.23E-04 | TCD |
| OTU_665 Ruminococcaceae UCG-014 | 9.1 | 3.26 | 2.20E-05 | 6.68E-04 | Siblings |
| OTU_130 Christensenellaceae R-7 group | 10.1 | 2.72 | 2.67E-05 | 7.39E-04 | Siblings |
| OTU_576 Akkermansia | 28.4 | –3.03 | 3.18E-05 | 8.43E-04 | TCD |
| OTU_80 Ruminococcaceae UCG-014 | 5.7 | 2.77 | 3.39E-05 | 8.60E-04 | Siblings |
| OTU_70 Ruminococcaceae UCG-014 | 5.2 | 2.75 | 4.15E-05 | 1.01E-03 | Siblings |
| OTU_178 Ruminococcaceae | 8.4 | 2.42 | 4.96E-05 | 1.16E-03 | Siblings |
| OTU_42 Methanobrevibacter | 17.2 | 3.21 | 5.55E-05 | 1.25E-03 | Siblings |
| OTU_908 Anaerostipes | 4.3 | 2.50 | 7.12E-05 | 1.46E-03 | Siblings |
| OTU_85 Bacteroidales S24-7 group | 6.5 | –2.68 | 7.21E-05 | 1.46E-03 | TCD |
| OTU_272 [Eubacterium] oxidoreducens group | 3.4 | 2.35 | 7.14E-05 | 1.46E-03 | Siblings |
| OTU_180 Ruminiclostridium 5 | 6.2 | 2.71 | 8.01E-05 | 1.57E-03 | Siblings |
| OTU_442 Christensenellaceae | 3.7 | 2.44 | 9.44E-05 | 1.80E-03 | Siblings |
| OTU_163 Ruminiclostridium 5 | 26.9 | –2.34 | 1.12E-04 | 2.07E-03 | TCD |
| OTU_33 Roseburia | 427.7 | –2.68 | 1.17E-04 | 2.09E-03 | TCD |
| OTU_622 Lachnospiraceae UCG-001 | 52.9 | –2.73 | 1.26E-04 | 2.20E-03 | TCD |
| OTU_783 Bacteroides | 4.4 | –2.05 | 2.31E-04 | 3.71E-03 | TCD |
| OTU_315 Christensenellaceae R-7 group | 8.9 | 2.40 | 2.25E-04 | 3.71E-03 | Siblings |
| OTU_337 Coriobacteriaceae | 7.0 | 2.45 | 2.31E-04 | 3.71E-03 | Siblings |
| OTU_67 Christensenellaceae R-7 group | 53.2 | 2.71 | 2.56E-04 | 4.00E-03 | Siblings |
| OTU_434 Christensenellaceae | 3.7 | 2.19 | 3.06E-04 | 4.55E-03 | Siblings |
| OTU_155 Lachnoclostridium | 23.8 | –2.56 | 3.25E-04 | 4.71E-03 | TCD |
| OTU_179 Howardella | 3.6 | 2.28 | 4.45E-04 | 6.30E-03 | Siblings |
| OTU_441 Thalassospira | 3.8 | 2.13 | 4.58E-04 | 6.34E-03 | Siblings |
| OTU_895 Barnesiella | 21.4 | –2.62 | 5.37E-04 | 7.26E-03 | TCD |
| OTU_868 Bacteroides | 112.1 | –2.68 | 6.00E-04 | 7.77E-03 | TCD |
| OTU_704 Collinsella | 91.7 | –2.16 | 6.34E-04 | 7.88E-03 | TCD |
| OTU_133 Flavonifractor | 82.0 | –2.07 | 9.31E-04 | 1.09E-02 | TCD |
| OTU_225 Butyrivibrio | 3.1 | 2.03 | 1.16E-03 | 1.26E-02 | Siblings |
| OTU_149 Lachnospiraceae NK4A136 group | 25.9 | –2.37 | 1.55E-03 | 1.58E-02 | TCD |
| OTU_195 Bacteroides plebeius DSM 17135 | 12.2 | –2.48 | 1.84E-03 | 1.81E-02 | TCD |
| OTU_116 Ruminococcaceae UCG-014 | 9.2 | 2.07 | 2.64E-03 | 2.40E-02 | Siblings |
| OTU_1105 Prevotella 9 | 192.5 | 3.03 | 3.33E-03 | 2.98E-02 | Siblings |
| OTU_137 Ruminococcaceae UCG-014 | 6.6 | 2.08 | 3.48E-03 | 3.05E-02 | Siblings |
| OTU_1049 Lachnoclostridium | 181.3 | –2.06 | 4.73E-03 | 3.60E-02 | TCD |
| OTU_63 Blautia | 388.5 | –2.06 | 4.87E-03 | 3.66E-02 | TCD |
| OTU_156 Christensenellaceae R-7 group | 58.7 | 2.25 | 4.94E-03 | 3.67E-02 | Siblings |
| OTU_1054 Alistipes | 45.1 | –2.01 | 5.82E-03 | 4.07E-02 | TCD |
NOTE. Log2-fold change is negative when the second group in the pairwise comparison has a lower relative abundance than the first group.