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Nisin biosynthesis. NisB, located at the old pole of the cell, recruits NisC to form a NisBC complex. NisA is bound and modified (step 1), and a NisBCT complex is formed by a fleeting interaction with NisT (step 2). The exported, modified nisin (step 3) is then cleaved by NisP before leaving the cell envelope (step 4).
