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. 2020 Dec 17;11:605338. doi: 10.3389/fimmu.2020.605338

Figure 2.

Figure 2

Proliferative responses to M. tuberculosis antigens. Briefly, PBMC were incubated with M. tuberculosis antigens for 6 days. Proliferating cells were identified as Celltrace violet low. (A, B) Celltrace low expression in CD4+ T-cells stimulated with CFP-10 pool or CFP-10 pool and ESAT-6 (A) U.S. study population. (B) Brazilian study population. (C, D) Celltrace low expression in CD4+ T-cells stimulated with gRV. Lines represent median values and interquartile ranges (IQR). The differences in median values (and IQR) between groups were compared using the Kruskal-Wallis test with Dunn’s multiple comparisons post-test. TB, tuberculosis; PTB, pulmonary tuberculosis; EPTB, extrapulmonary tuberculosis; TST, tuberculin skin test; CFP, Culture filtrate protein; ESAT, early secretory antigen of tuberculosis; gRV, γ-irradiated M. tuberculosis.