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. 2020 Dec 17;11:591227. doi: 10.3389/fphar.2020.591227

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Copyright © 2020 Shan, Zhang, Gao, Liang, Zhang, Yu, Zhao, Ye, Yang and Shang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of inflammatory response in obese mice by BBR was weakened by knockout of SIRT1. Wild Type (WT) or Sirt ^+/− (KO) C57BL/6 mice fed normal chow (NC) or high-fat diet (HFD) were treated with 50 mg/kg (BH) BBR for 2 weeks. (A–C) Serum inflammatory factors were measured (n = 6). (B,C) Relative expression of inflammatory factors in epididymal adipose tissue was quantified by real-time PCR (n = 3). (G,H) Phosphorylation of JNK and IKKβ in epididymal adipose tissue was measured by Western blotting. Band intensities were quantified by normalizing to the corresponding total protein levels (n = 3). (I) F4/80-positive macrophages in epididymal white adipose tissue were measured by immunohistochemistry. Quantitative data are presented as mean ± SD. *p < 0.05.