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. 2020 Dec 30;78(4):1–10. doi: 10.1001/jamapsychiatry.2020.4064

Figure 1. Study Design of Identifying Altered Fiber Tract Development Associated With Adolescent Alcohol Use.

Figure 1.

Of the 782 National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) participants with at least 2 usable diffusion tensor imaging (DTI) scans, 291 youth were labeled as no-to-low drinkers (youth-adjusted Cahalan = 0) throughout the 4-year study period, and 160 were heavy drinkers (youth-adjusted Cahalan >1) for at least 2 consecutive visits. The analysis examined the association of alcohol with white matter microstructure during adolescence based on (1) a between-group analysis on 78 no-to-low drinkers and 78 age- and sex-matched heavy drinkers and (2) a within-participant analysis on 63 transitioners who were no-to-low drinkers for at least 2 visits before initiating heavy drinking. The differential alcohol outcome with respect to age was examined in the 39 younger and 39 older youth in each matched cohort.