TABLE 6.

Differential metabolites detected in mouse serum by UHPLC-Q-Orbitrap-MS/MS.

No.	Metabolite	t R/min	Formula	m/z	Ion	VIP (>1)
1	Oleamide	26.098	C18H35NO	282.2717	[M+H]+	30.4936
2	Hexadecanamide	25.11	C16H33NO	256.25601	[M+H]+	15.4175
3	Stearamide	28.837	C18H37NO	284.28736	[M+H]+	9.10991
4	Acetyl-l-carnitine	1.597	C9H17NO4	204.11568	[M+H]+	5.74342
5	2-Oxoglutaric acid	1.6	C5H6O5	145.02105	[M−H]−	3.69693
6	Isocitric acid	1.582	C6H8O7	191.02656	[M−H]−	3.43281
7	dl-Tryptophan	5.783	C11H12N2O2	205.08979	[M+H]+	4.79669
8	Isoleucine	1.604	C6H13NO2	132.09464	[M+H]+	3.60728
9	Creatine	1.351	C4H9N3O2	132.06951	[M+H]+	2.98949
10	Acetyl-β-methylcholine	1.576	C8H17NO2	160.12585	[M+H]+	3.80388
11	l-Phenylalanine	1.656	C9H11NO2	166.07894	[M+H]+	2.81315
12	Valine	1.591	C5H11NO2	116.07912	[M−H]−	2.72165
13	Citric acid	2.349	C6H8O7	191.02668	[M−H]−	3.69294
14	dl-Carnitine	1.313	C7H15NO3	162.10514	[M+H]+	1.71998
15	N,N-Dimethylsphingosine	29.381	C20H41NO2	328.50292	[M+H]+	2.51312
16	Betaine	1.287	C5H11NO2	118.07911	[M+H]+	2.34196
17	Butyryl-l-carnitine	5.743	C11H21NO4	232.14691	[M+H]+	1.48593
18	Methionine	1.602	C5H11NO2S	150.051	[M+H]+	2.19918
19	Palmitoylcarnitine	18.383	C23H45NO4	400.33466	[M+H]+	1.54599
20	Proline	1.358	C5H9NO2	116.0635	[M+H]+	1.5666
21	Choline	1.259	C5H13NO	104.09999	[M+H]+	1.24409
22	l-γ-Glutamyl-l-leucine	5.773	C11H20N2O5	259.13695	[M−H]−	1.42737
23	d-(+)-Malic acid	1.56	C4H6O5	133.02075	[M−H]−	1.4384
24	2-Hydroxyphenylalanine	3.135	C9H11NO3	182.07381	[M+H]+	1.16375
25	6-Methylquinoline	5.789	C10H9N	144.07345	[M+H]+	1.31423
26	Indole	5.777	C8H7N	118.05792	[M+H]+	1.42674
27	Acetylcholine	1.38	C7H15NO2	146.11026	[M+H]+	1.48906
28	Propionylcarnitine	1.619	C10H19NO4	218.13125	[M+H]+	1.05437
29	Hexanoylcarnitine	6.526	C13H25NO4	260.17825	[M+H]+	1.11086