Table 1. IC50 Values (μM) of Sanjoseolide (1) and Their Derivatives against Cholangiocarcinoma Cell Linesa.
compound | REB | HCCC-9810 |
---|---|---|
7a | 25.7 ± 0.5 | 31.0 ± 1.0 |
11 | 59.1 ± 3.8 | 101.1 ± 1.8 |
10 | 28.3 ± 1.4 | 29.5 ± 1.4 |
8b | 73.2 ± 2.6 | 102.5 ± 4.4 |
8c | 105.0 ± 2.8 | 124.0 ± 7.4 |
8d | 31.2 ± 1.0 | 20.5 ± 1.6 |
8e | 12.8 ± 0.4 | 12.7 ± 0.6 |
sanjoseolide(1) | 15.7 ± 0.3 | 15.6 ± 1.2 |
cisplatin | 5.0 ± 0.3 | 1.8 ± 0.11 |
Data presented as a mean ± standard deviation (SD) of three replicate measurements of the same sample.