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. 2020 Nov 26;11:523962. doi: 10.3389/fphar.2020.601344

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Copyright © 2020 Mong, Tarjanyi, Tothfalusi, Bartykowszki, Nagy, Szekely, Becker, Maurovich-Horvat, Merkely and Nagy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Arterial age difference depends on the disease duration. The effect of disease duration on the arterial age difference between RA patients and controls is shown. The smoothed curve in the left figure was obtained with Lowess. On the right figure, the red line represents the fitted regression line. The slope of the regression line (slope = 0.395, t = 2.74, p = 0.007) is the yearly divergence rate from the control. In both cases, the shaded areas around the lines are the 95% confidence intervals. The arterial aging is approximately 40% accelerated.