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A summary of the effect and mechanism of the anti-DDP-induced muscle atrophy of LIN. LIN comes from a variety of Chinese herbal medicines, fruits and spices, and is widely distributed in nature. LIN can improve the cachexia symptoms of DDP-treated tumour-bearing mice and reduce muscle atrophy without affecting the anti-tumor efficacy of DDP. The mechanism is that LIN can down-regulate the expression of Atrogin1 and MuRF1 through the IGF-1/Akt/FoxO pathway to alleviate muscle atrophy.
