TABLE 5.

Umami receptor agonists with their EC50 values and other pharmacological properties.

Agonist	Nature	EC50 (mM)	Binding pocket	References
L-amino acids (glutamate, aspartate, alanine, serine, asparagine, arginine, histidine, threonine, glutamine)	Amino acids	3 (glutamate), ND for others	VFT (TAS1R1)	(Li et al., 2002; Nelson et al., 2002; Zhang et al., 2008; Toda et al., 2013)
L-theanine	Amino acid (plant origin)	ND	VFT (TAS1R1)	(Narukawa et al., 2014)

VFT, venus flytrap domain; ND, not determined.