TABLE 6.
Umami receptor allosteric modulators with conc. used in cell based assays and other pharmacological properties.
| Allosteric modulators | Nature | Conc. (mM) | Binding pocket | References |
|---|---|---|---|---|
| IMP/GMP | Nucleotide | 1 | VFT (TAS1R1) | (Li et al., 2002; Nelson et al., 2002; Zhang et al., 2008) |
| Cyclamate | Sodium cyclohexylsulfamate | 8 | TMD (TAS1R3) | (Xu et al., 2004) |
| Methional (3-methylsulfanylpropanal) | — | 0.12 | TMD (TAS1R3) | (Toda et al., 2018) |
| Lactisole (2-4-methoxyphenoxy propionic acid) | Carboyxlic acid salt | 5 | TMD (TAS1R3) | (Xu et al., 2004) |
| Clofibric acid (4- chlorophenoxy)-2-methylpropanoic acid | Herbicide acid | 4 | TMD (TAS1R3) | (Maillet et al., 2009; Kochem and Breslin, 2017) |
Where VFT, Venus flytrap domain; TMD, transmembrane domain.