Skip to main content
. 2020 Nov 30;11:603226. doi: 10.3389/fphar.2020.603226

FIGURE 1.

FIGURE 1

Effect of red blood cells (RBCs) on endothelial function. Effect of RBCs from type 2 diabetes patients (T2D RBC), healthy subjects (H RBC) or buffer only on endothelium-dependent relaxation (EDR) in rat aortas induced by acetylcholine (ACh) (A: n = 15-17). EDR in aortas of healthy recipient rats transfused with RBCs from GK (GK RBC) or Wistar rats (WT RBC) (B: GK RBC n = 12, WT RBC n = 6). Effect of the non-selective P1R antagonist 8PT and the non-selective P2R antagonist PPADS on EDR in rat aortas incubated with T2D RBC (C: n = 8, E: n = 5) or H RBC (D: n = 4, F: n = 6). Values are mean ± SD. *p < 0.05 effect of antagonist; ***p < 0.01 vs. buffer; †††p < 0.001 vs. H RBC or WT RBC.