FIGURE 7.

CD73 alleviates GSDMD‐mediated pyroptosis through inhibiting PI3K/AKT/Foxo1 signaling. CD73 promotes an increase in the concentration of extracellular adenosine after injury, increases PI3K/AKT activation through the A_2B adenosine receptor, thereby blunting NLRP3 inflammasome activation and reducing GSDMD transcription. The accumulation of HIF‐1α after spinal cord injury facilitates the upregulation of CD73, while the overexpressed CD73 promotes the further aggregation of HIF‐1α through adenosine‐A_2BAR‐p38 cascade, forming a positive feedback regulation. This picture is drawn with BioRender (www.biorender.com)