Figure 4.

HeartBioPortal2.0’s genetic ancestry and variant geography feature. CVD-relevant exome/genome population allele frequency data displayed in the Ancestry and Variant Geography maps from dozens of studies/cohorts ranging from gnomAD to ‘Genome of the Netherlands Release 5’ to ‘Korean population from KRGDB’ among many others. In total, 54 diverse subpopulations across 27 new studies/cohorts have been added, relative to gnomAD alone in HeartBioPortal’s initial debut in May 2019. Users can now search individual mutations (rsID accession identifiers) as well as toggle a Minor Allele Frequency (MAF) slider bar that interactively displays the proportion of rare vs. common variants at user-selected MAF thresholds.