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. 2020 Nov 24;11:563157. doi: 10.3389/fphar.2020.563157

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Copyright © 2020 Li, Wen, Wen, Yan, Wu, Guo, Li, Gong and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative content of common metabolites in the CPS, SPS, and NC groups vs. the M group. ^# p < 0.05 vs. the NC group; *p < 0.05 vs. the M group; **p < 0.01, vs. the M group. (A) Linoleic acid; (B) lysoPC(18:0); (C) lysoPC(O-18:0); (D) PC(18:1(9Z)e/2:0); (E) sphingosine-1-phosphate; and (F) sphinganine. Six common but major feature metabolites of the CPS and SPS groups were significantly reversed compared to the M group with using a multiple t-test and the results were showed in the plots.