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. 2020 Nov 26;11:596046. doi: 10.3389/fphar.2020.596046

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Copyright © 2020 Zou, Yuan, Zhang, Wang, Chen, Yuan, Bian and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cd inhibits the GJIC in BRL 3A cells. (A) Following treatment with 5 μmol/L Cd for different time periods, GJIC was measured by the SL/DT method (scale bar = 50 μm). (B) Quantification of data obtained for the LY transfer distance depicting the spread of the dye from each side of the wound area (n = 6). (C) 5 μmol/L Cd disrupts Cx43 distribution in BRL 3A cells.Cx43 expression (green) and the presence of the nuclei (blue) were observed and imaged using confocal microscopy. Scale bar = 10 μm. (D–F) Cd treatment at different time periods affects the levels of connexin expression in BRL 3A cells. Compared with the control group, *p < 0.05, **p < 0.01; compared with the indicated group, ^# p < 0.05, ^## p < 0.01.