TABLE 4.

Clinical studies concerning the evaluation of efficacy of the main constituents of essential oil preparation from Thymbra capitata (L.) Cav., Salvia fruticosa Mill. and Origanum dictamnus L., in several medical conditions.

Compound	Symptome	Clinical trial	References
1,8-cineol (eucalyptol)	Anti-inflammatory activity in bronchial asthma	Double-bind placebo-controlled trial	Juergens et al. (2003)
Cineole	Acute nonpurulent rhinosinusitis	Double-blind, randomized, placebo-controlled trial	Kehrl et al. (2004)
Cineole	Acute non-purulent rhinosinusitis	Prospective, randomised, double-blinded controlled study	Tesche et al. (2008)
Cineole (eucalyptole)	Chronic obstructive pulmonary disease	Placebo-controlled double-blind trial	Worth et al. (2009)
Cineole	Asthma	Placebo-controlled, double-blind trial	Worth and Dethlefsen (2012)
Cineole	Acute bronchitis	Placebo-controlled double-blind trial	Fischer and Dethlefsen (2013)
1,8-cineol (in eucalyptus oil)	Pain and inflammatory responses after total knee replacement	Randomized clinical trial	Jun et al. (2013)
1,8-Cineole	Preoperative anxiety	Randomized clinical trial	Kim et al. (2014)