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. 2021 Jan;27(1):140–149. doi: 10.3201/eid2701.190676

Table 2. Estimated number of total cases of domestically acquired waterborne illness in 2014 for selected infectious diseases, United States* .

Disease or syndrome Estimated confirmed cases Multipliers
Estimated total cases (95% CrI) International travel, % Waterborne, % (95% CrI) Domestically acquired waterborne, no. (95% CrI)
Under-reporting Under-diagnosis
Campylobacteriosis 54,000 1.0 28.3 1,540,000
(597,000–3,250,000) 14.4 13
(1–31) 171,000
(13,900–586,000)
Cryptosporidiosis 8,450 1.0 97.3 823,000
(243,000–2,160,000) 9.9 43
(17–73) 322,000
(61,700–993,000)
Giardiasis 17,900 1.30 45.9 1,070,000
(727,000–1,560,000) 12.3 44
(16–78) 415,000
(140,000–816,000)
Legionnaires’ disease 5,030 1.0 2.3 11,400
(8,920–13,600) 1.0 97
(67–100) 11,000
(7,430–13,300)
NTM infection 25,700 1.0 3.8 97,000
(75,700–122,000) 1.0 72
(39–94) 68,900
(35,800–100,000)
Norovirus NA 1.0 NA 21,800,000
(12,100,000–36,000,000) 1.1 6
(0–25) 1,330,000
(5,310–5,510,000)
Otitis externa† 1,720,000 1.0 3.4 5,980,000
(3,200,000–8,880,000) 1.3 79
(67–95)† 4,670,000
(2,350,000–7,290,000)
Pseudomonas pneumonia 15,800 1.0 2.0 31,700
(19,300–46,000) 1.0 51
(14–80) 15,900
(4,240–29,000)
Pseudomonas septicemia 13,000 1.0 2.0 26,100
(16,700–35,900) 1.0 22
(3–53) 5,760
(743–14,400)
Salmonellosis, nontyphoidal 46,400 1.0 29.1 1,350,000
(733,000–2,450,000) 9.7 6
(0–22) 77,000
(5,640–277,000)
STEC infection, serotype O157 3,530 1.0 18.2 64,200
(13,000–188,000) 4.0 5
(1–13) 3,360
(336–12,900)
STEC infection, serotype non-O157 4,550 1.0 48.1 219,000
(80,000–493,000) 15.3 6
(0–17) 11,400
(0–43,900)
Shigellosis
13,600
1.0
33.1
449,000
(97,800–1,350,000)
7.8
4
(1–21)
17,300
(1,080–77,500)
Vibrio spp. infection 1,230 NA NA 172,000
(126,000–231,000) NA NA 34,600
(17,600–56,900)
  V. alginolyticus 234 1.1 142.8 36,700
(23,600–54,800) 6.5 37
(13–71) 12,700
(4,100–25,400)
  V. parahaemolyticus 593 1.1 141.6 92,400
(55,000–144,000) 6.7 24
(7–38) 20,800
(6,000–39,000)
  V. vulnificus 133 1.1 1.7 249
(178–340) 1.5 77
(40–91) 188
(93–277)
  Other Vibrio
271
1.1
142.8
42,600
(25,500–66,500)
14.4
2
(0–23)
879
(3–8,490)
Total illness NA NA NA 33,600,000
(23,500,000–48,000,000) NA NA 7,150,000
(3,880,000–12,000,000)

*Estimates rounded to 3 significant figures. CrI, credible interval; NA, not applicable; NTM, nontuberculous mycobacteria; STEC, Shiga toxin–producing Escherichia coli.
†Combines the waterborne source attribution (25) for Pseudomonas spp. otitis externa (81%) and Staphylococcus aureus (75%) in a ratio of 2:1. More details provided in Appendix 1 (https://wwwnc.cdc.gov/EID/article/27/1/19-0676-App1.pdf).