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. 2021 Jan;27(1):47–56. doi: 10.3201/eid2701.191220

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Photomicrographs of liver from human patient (A, C) and Callicebus spp. monkey (B, D) with full spectrum of yellow fever (YF)–associated lesions, Brazil. Midzonal necrosis with multiple Councilman-Rocha Lima bodies (arrows), mild steatosis, and hepatocytes with eosinophilic nucleoli (Torres body [Xs]) (hematoxylin and eosin stained). B) Necrosis/apoptosis (diffuse and panlobular), associated with multiple Councilman-Rocha Lima bodies (arrows) and a few remaining viable hepatocytes (arrowheads) in periportal area (hematoxylin and eosin stained). C) Positive, multifocal immunolabeling for YF antigen (arrowheads) (anti-YF, Warp red, counterstained with hematoxylin). D) Intense and diffuse immunolabeling for YF antigen (anti-YF, 3,3'-diaminobenzidine counterstaining with hematoxylin). Scale bars indicate 50 µm.