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. 2020 Dec 17;10:602670. doi: 10.3389/fonc.2020.602670

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Copyright © 2020 Quiñones-Díaz, Reyes-González, Sánchez-Guzmán, Conde-Del Moral, Valiyeva, Santiago-Sánchez and Vivas-Mejía

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Therapeutic effect of targeting miR-18a in vivo and miR-18a clinical relevance. Folate liposomal miR-18a-OMM (miR-18a-LF, N= 16) or CNT-OMM (CNT-LF, N=14) were administered twice a week in intraperitoneal xenograft mouse models of ovarian cancer. (A) tumor weight (B) number of nodules. Mean ± SEM is shown (*P < 0.05). (C) Kaplan-Meier (KM) plot shows that the OS is increased for ovarian cancer patients with higher miR-18a expression levels. Plot was generated using the Kaplan–Meier (KM) plotter (www.kmplot.com).