TABLE 1.
Correlation between patient‐ and physician‐reported outcomes for each symptom at 4 weeks
| Symptoms a | No. (%) of reports based on the questionnaire b | Overall Agreement | Cohen's κ (95% CI) | |||
|---|---|---|---|---|---|---|
| Agreement | Disagreement | |||||
| Patient No / Physician No | Patient Yes / Physician Yes | Patient Yes / Physician No | Patient No / Physician Yes | |||
| Fatigue | 8 (6.3) | 43 (33.9) | 72 (56.7) | 4 (3.2) | 40.2% | 0.01 (−0.07–0.09) |
| Pain | 62 (48.8) | 3 (2.4) | 60 (47.2) | 2 (1.6) | 51.2% | 0.02 (−0.05–0.09) |
| Sleep | 60 (46.9) | 1 (0.8) | 66 (51.6) | 1 (0.8) | 47.7% | −0.001 (−0.04–0.04) |
| Dyspnea | 73 (57.5) | 1 (0.8) | 53 (41.7) | 0 (0) | 58.3% | 0.02 (−0.02–0.06) |
| Constipation | 60 (47.6) | 21 (16.7) | 40 (31.8) | 5 (4.0) | 64.3% | 0.27 (0.13–0.41) |
| Appetite | 63 (50.0) | 29 (23.0) | 25 (19.8) | 9 (7.1) | 73.0% | 0.43 (0.27–0.58) |
| Nausea/Vomiting | 78 (60.9) | 20 (15.6) | 16 (12.5) | 14 (10.9) | 76.5% | 0.41 (0.24–0.59) |
| Diarrhea | 72 (57.1) | 21 (16.7) | 31 (24.6) | 2 (1.6) | 73.8% | 0.41 (0.26–0.56) |
| Symptoms | No. (%) of reports based on the difference of scales c | Overall Agreement | Cohen's κ (95% CI) | |||
|---|---|---|---|---|---|---|
| Agreement | Disagreement | |||||
| Patient No / Physician No | Patient Yes / Physician Yes | Patient Yes / Physician No | Patient No / Physician Yes | |||
| Fatigue | 43 (34.1) | 21 (16.7) | 37 (29.4) | 25 (19.8) | 50.8% | −0.006 (−0.18–0.17) |
| Pain | 81 (63.8) | 0 (0) | 41 (32.3) | 5 (3.9) | 63.8% | 0.03(−0.12–0.18) |
| Sleep | 93 (73.2) | 1 (0.8) | 33 (26.0) | 0 (0) | 74.0% | 0.04 (−0.04–0.12) |
| Dyspnea | 96 (76.2) | 0 (0) | 30 (23.8) | 0 (0) | 76.2% | 0.0 (NE) |
| Constipation | 80 (63.5) | 12 (9.5) | 20 (15.9) | 14 (11.1) | 73.0% | 0.241 (0.05–0.43) |
| Appetite | 75 (60.0) | 16 (12.8) | 12 (9.6) | 22 (17.6) | 72.8% | 0.31 (0.13–0.49) |
| Nausea/Vomiting | 82 (64.6) | 17 (13.4) | 12 (9.5) | 16 (12.6) | 78.0% | 0.40 (0.22–0.59) |
| Diarrhea | 89 (70.6) | 14 (11.1) | 14 (11.1) | 9 (7.1) | 81.7% | 0.44 (0.24–0.63) |
| Skin‐related toxicity | 12 (10.4) | 33 (28.7) | 2 (1.7) | 68 (59.1) | 39.1% | 0.06 (−0.01–0.14) |
For skin‐related toxicity, the Dermatology Life Quality Index (DLQI) was used, which was defined as symptomatic if a change in DLQI score of at least four points.
Cohen's κ values: less than 0.00, poor agreement (gray); values between .00 and .20, slight agreement (gray); values between .21 and .40, fair agreement; values between .41 and .60, moderate agreement (bold).
Abbreviation: NE, not evaluable.
Physician‐reported outcome for each symptom was defined as positive if they had more than grade 1 according to the NCI‐CTC version 4.0.
Patient‐reported outcome for each symptom was defined as symptomatic if they answered “a little,” “quite a bit,” or “very much” to at least one of the symptom questions and asymptomatic if they answered “not at all” to all of the symptoms according to the EORTC QLQ‐C30.
Patient‐reported outcome for each symptom was defined as symptomatic if they had a difference of more than 10 points in change scores from baseline and asymptomatic if they had a difference of less than 10 points according to the EORTC QLQ‐C30.