TABLE 2.
Characteristics of the Cohort at Baseline
| Dapansutrile 500 mg (n = 8) | Dapansutrile 1000 mg (n = 8) | Dapansutrile 2000 mg (n = 8) | All Dapansutrile Subjects (n = 24) | Pooled Placebo Subjects (n = 6) | |
| Vitals | |||||
| SBP, mm Hg | 128 (122–131) | 123 (117–136) | 113 (105–125) | 122 (115–131) | 119 (116–134) |
| DBP, mm Hg | 76 (74–80) | 75 (69–81) | 71 (64–79) | 75 (70–81) | 74 (65–76) |
| HR, bpm | 74 (69–80) | 76 (71–83) | 70 (64–78) | 73 (69–80) | 85 (74–92) |
| Temperature, °C | 36.7 (36.4–36.8) | 36.9 (36.6–37.0) | 36.6 (36.5–36.9) | 36.8 (36.5–36.9) | 36.8 (36.7–36.8) |
| Respiratory rate, brpm | 18 (16–20) | 18 (17–18) | 18 (16–18) | 18 (16–18) | 20 (18–20) |
| Body composition | |||||
| BMI, kg/m2 | 33.7 (25.8–40.3) | 34.9 (31.8–39.6) | 33.5 (31.9–38.0) | 33.8 (30.8–38.1) | 37.2 (31.1–48.8) |
| Fat mass index, kg/m2 | 13.6 (7.8–15.2) | 12.5 (10.1–15.2) | 12.6 (11.5–17.9) | 12.9 (10.7–15.3) | 15.6 (9.6–20.9) |
| Extracellular water, L | 21.7 (14.7–27.6) | 23.4 (21.2–27.1) | 19.7 (17.7–21.6) | 21.3 (17.9–24.6) | 21.7 (19.7–25.2) |
| Intracellular water, L | 22.9 (20.3–32.2) | 29.7 (26.4.32.7) | 25.3 (18.3–28.7) | 27.3 (21.6–30.1) | 23.0 (20.1–27.5) |
| Echocardiography | |||||
| LVEF, % | 30 (26–36) | 31 (22–35) | 32 (28–39) | 31 (25–37) | 34 (30–36) |
| e', cm/s | 5.50 (4.25–6.80) | 6.93 (4.25–10.20) | 5.90 (5.13–7.65) | 5.90 (4.63–7.65) | 6.68 (4.50–8.90) |
| E/e' | 11.00 (8.73–19.50) | 12.05 (8.35–21.45) | 9.40 (7.60–13.90) | 10.55 (8.15–16.35) | 14.00 (11.50–16.20) |
| LAV, mL | 75 (67–103) | 102 (83–126) | 63 (55–95) | 79 (61–111) | 86 (71–99) |
| LVEDV, mL | 213 (164–241) | 207 (176–279) | 156 (121–200) | 200 (155–222) | 179 (117–229) |
| LVESV, mL | 150 (115–169) | 144 (117–215) | 113 (78–130) | 139 (97–157) | 116 (82–163) |
| TAPSE, cm | 2.15 (1.85–2.58) | 1.85 (1.35–2.15) | 2.51 (2.05–2.80) | 2.10 (1.80–2.57) | 1.48 (1.20–2.00) |
| CPX | |||||
| Exercise time, s | 569 (444–658) | 545.0 (450–660) | 570 (429–621) | 570 (444–649) | 365 (340–483) |
| Peak RER | 1.04 (1.02–1.06) | 1.13 (1.04–1.24) | 1.12 (1.03–1.22) | 1.06 (1.02–1.18) | 1.26 (1.11–1.40) |
| Peak VO2, mL/kg/min | 15.3 (13.6–17.3) | 14.5 (12.0–16.7) | 14.2 (12.1–17.3) | 15.0 (12.4–17.0) | 10.4 (9.9–15.7) |
| VE/VCO2 slope | 32.4 (31.5–39.3) | 28.2 (24.2–34.2) | 31.7 (30.3–33.3) | 31.8 (28.5–33.6) | 32.2 (30.1–37.8) |
BMI, body mass index; bpm, beats per minute; brpm, breaths per minute; DBP, diastolic blood pressure; LAV, left atrium volume; LVEDV, left ventricular end-diastolic volume; LVESV, left ventricular end-systolic volume; SBP, systolic blood pressure.