TABLE 3.
Laboratory Findings of the Cohort at Baseline
| Dapansutrile 500 mg (n = 8) | Dapansutrile 1000 mg (n = 8) | Dapansutrile 2000 mg (n = 8) | All Dapansutrile Subjects (n = 24) | Pooled Placebo Subjects (n = 6) | |
| Chemistry | |||||
| ALT, U/L | 20 (13–36) | 15 (12–17) | 16 (14–23) | 16 (13–23) | 32 (22–36) |
| AST, U/L | 22 (18–31) | 18 (17–22) | 19 (18–22) | 19 (17–24) | 29 (25–42) |
| Bilirubin, mg/dL | 0.40 (0.35–0.70) | 0.70 (0.40–0.80) | 0.55 (0.45–0.65) | 0.50 (0.40–0.75) | 0.65 (0.60–0.70) |
| Lipase, U/L | 38 (23–53) | 38 (22–58) | 22 (19–32) | 29 (21–42) | 56 (13–59) |
| Total protein, g/dL | 7.15 (6.60–7.25) | 7.10 (7.00–7.30) | 7.35 (6.95–7.60) | 7.20 (6.85–7.40) | 7.20 (6.90–8.00) |
| Albumin, g/dL | 4.15 (4.00–4.50) | 4.20 (4.05–4.40) | 4.25 (4.20–4.40) | 4.20 (4.00–4.40) | 4.40 (3.50–4.50) |
| hsCRP, mg/L | 5.23 (2.62–7.36) | 3.46 (1.97–5.32) | 4.10 (2.29–20.75) | 4.10 (2.35–5.93) | 6.10 (2.87–17.12) |
| Creatinine, mg/dL | 1.16 (0.78–1.40) | 0.97 (0.87–1.12) | 0.94 (0.89–1.15) | 0.99 (0.86–1.19) | 1.03 (0.96–1.21) |
| Cystatin C, mg/L | 1.10 (0.89–1.74) | 1.08 (0.78–1.25) | 1.10 (0.94–1.34) | 1.08 (0.87–1.42) | 1.35 (0.85–1.64) |
| BUN, mg/dL | 14.5 (10.5–20.0) | 13.0 (13.0–16.0) | 15.5 (13.5–19.5) | 14.5 (13.0–17.0) | 19.0 (14.0–24.0) |
| Sodium (mmol/L) | 139 (138–139) | 138 (136–138) | 139 (136–140) | 138 (137–139) | 137 (134–138) |
| Potassium, mmol/L | 4.25 (3.80–4.50) | 4.15 (3.75–4.40) | 4.05 (3.80–4.35) | 4.15 (3.80–4.45) | 4.55 (4.30–4.80) |
| Chloride, mmol/L | 103 (102–107) | 104 (103–105) | 105 (98–106) | 104 (102–106) | 100 (97–102) |
| Calcium, mg/dL | 9.60 (9.40–9.80) | 9.40 (9.15–9.60) | 9.50 (9.15–9.60) | 9.50 (9.20–9.65) | 9.60 (9.30–10.00) |
| FPG, mg/dL | 131 (109–160) | 158 (91–192) | 128 (95–168) | 138 (98–173) | 125 (102–323) |
| HbA1c, % | 5.80 (5.25–7.25) | 7.60 (5.65–7.80) | 6.40 (6.00–8.40) | 6.40 (5.60–7.80) | 7.35 (5.80–9.70) |
| NT-proBNP, pg/mL | 631 (246–1478) | 641 (110–841) | 334 (263–958) | 520 (228–965) | 1549 (148–2207) |
| CBC | |||||
| WBC, 109/L | 7.15 (6.60–9.50) | 5.80 (5.10–8.60) | 6.35 (5.60–7.40) | 6.75 (5.45–8.60) | 6.95 (6.50–7.50) |
| Neutrophils, 109/L | 3.85 (3.50–6.05) | 3.60 (2.70–5.90) | 3.50 (3.20–4.70) | 3.60 (3.20–5.65) | 4.70 (3.50–5.40) |
| Lymphocytes, 109/L | 2.30 (1.85–2.80) | 1.60 (1.15–2.05) | 1.95 (1.75–2.20) | 1.95 (1.65–2.25) | 1.95 (1.20–2.30) |
| Monocytes, 109/L | 0.55 (0.40–0.75) | 0.55 (0.50–0.70) | 0.55 (0.35–0.60) | 0.55 (0.40–0.60) | 0.55 (0.50–0.70) |
| Basophils, 109/L | 0.00 (0.00–0.05) | 0.00 (0.00–0.05) | 0.00 (0.00–0.10) | 0.00 (0.00–0.10) | 0.05 (0.00–0.10) |
| Eosinophils, 109/L | 0.15 (0.10–0.30) | 0.10 (0.10–0.20) | 0.15 (0.10–0.20) | 0.10 (0.10–0.20) | 0.10 (0.10–0.20) |
| RBC, 1012/L | 4.76 (4.21–5.10) | 4.50 (4.06–5.14) | 4.48 (4.41–4.67) | 4.48 (4.24–5.05) | 4.32 (3.99–4.85) |
| Hematocrit, % | 41 (40–43) | 42 (38–43) | 39 (37–41) | 40 (38–43) | 40 (37–42) |
| Hemoglobin, g/dL | 13.60 (12.70–13.85) | 13.50 (12.75–14.35) | 12.70 (11.75–13.65) | 13.35 (12.55–13.85) | 13.10 (12.20–14.00) |
| Platelets, 109/L | 257 (197–283) | 232 (176–246) | 210 (197–230) | 224 (195–253) | 237 (202–291) |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; CBC, complete blood count; RBC, red blood cells; WBC, white blood cells.