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. 2020 Dec 31;15(12):e0236495. doi: 10.1371/journal.pone.0236495

Table 4. Jacobian determinant standard deviation (JSD) and Hessian frobenius norm mean (HFM) where templates are sorted by descending JSD for a fixed algorithm (ANTs A).

Template JSD HFM
ANTs A CMTK A Elastix A ANTs A CMTK A Elastix A
JFRC2010 0.26 0.19 0.18 0.032 0.014 0.0029
JFRC2013 0.23 0.26 0.23 0.039 0.017 0.013
JRC2018F 0.20 0.21 0.17 0.035 0.025 0.018
FCWB 0.47 0.32 0.23 0.051 0.038 0.0047
Tefor 0.26 0.23 0.14 0.040 0.019 0.0033

This algorithm has the capability of producing large deformations (i.e. it is not overly regularized), as by the large value of JSD for the FCWB template. The smallest average amount of deformation was obtained after registration to our template, JRC 2018F, followed closely by JFRC 2013.