Table 1A.

A) APOE haplotype association with AD. Odds ratios, confidence intervals and p-values are obtained from a logistic regression model controlling for confounders and the dosages of the different haplotypes. ε3 is taken as the reference haplotype. A) Haplotype analysis of individuals of European descent (EU) in NACC. Analysis restricted to EU individuals

Name	Haplotype	Age of onset	AD	CTR	OR	95% CI	P
E3	GTC	72.9	0.601	0.77
E2	GTT	75.3	0.036	0.075	0.58	[0.49–0.69]	4.70E–10
E4 Ancestral	GCC	70.2	0.078	0.034	3.61	[3.04–4.27]	4.50E–50
E4 European	ACC	69.6	0.285	0.122	3.48	[3.15–3.84]	1.60E–132
			3106	3797